To uninstall updates: Click Right on "Windows" icon > and go to "Control Panel" option. Restart "Microsoft Outlook" or reboot your machine. When you click on "Modify.", a pop-up box will be appear, type 1 in Value data field > hit on "OK" button. Click Right on DisableSafeMode > hit on "Modify…" button. Type DisableSafeMode > press Enter button. Click Right on "Security" folder > choose "New" > "DWORD (32-bit) Value". 
Now, you need to follow this path: HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\Outlook\Security\
A new window will open named as "Registry Editor". A Run dialog box will be open, now type "regedit" and click on "OK" button. In short, you can also press "Start" Key + "R". Right click on "Windows" icon > and go to "Run" option to open run dialog box. First you have to uninstall KB3114409 update and the second solution is you have to fix the registry key to disable this functionality (Safe mode). To Solve Outlook safe mode issue, you have two options. This Outlook safe mode issue caused because of installation of KB3114409 update and that's why your Microsoft Outlook always opens in safe mode rather than opening it in default mode. but nothing happened and it still starts in safe mode. You have tried all possible solutions like Inbox Repair Tool (scanpst.exe), disabling add-ins, reset navigation pane, etc. 
Whenever you open Microsoft Outlook 2010 under Windows 10, it always starts in safe mode. Outlook Always Opening in Safe Mode Problem:
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